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Prevention in heart health.

Exploring how mesenchymal stem cells could support performance and promote healthier lives as we grow oExploring how mesenchymal stem cells can lower the risk of cardiovascular disease.

The silent progression of cardiovascular disease

Cardiovascular disease (CVD) often strikes without warning, but in reality, it builds up silently for years through inflammation, vessel dysfunction, and gradual vascular damage.3 Most treatments today begin only after a heart attack, stroke, or other critical event has occurred.

What is cardiovascular disease?

CVD is a group of disorders affecting the heart and blood vessels, including coronary artery disease, heart attack, stroke, arrhythmias, and heart failure.2,3

Why mesenchymal stem cells are being explored in cardiovascular disease

Mesenchymal stem cells are being investigated for their potential to act earlier in the disease process — reducing low-grade inflammation, supporting vascular function, and protecting heart tissue before irreversible damage occurs.4-7

What we’re starting to see

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Early clinical research is beginning to provide evidence on the potential role of mesenchymal stem cells in cardiovascular prevention.

500+

Patients



A 2023 study included more than 500 patients with heart failure, with a 30-month follow-up after targeted transendocardial mesenchymal precursor cell therapy.9

Reduced incidence of heart attack and stroke

The current page says patients treated with mesenchymal stem cells experienced a reduced incidence of heart attack and stroke, particularly those with systemic inflammation.9

Improved cardiac performance

The same trial reported improved cardiac performance measured by left ventricular ejection fraction (LVEF).9

62

RCTs



A 2021 meta-analysis of 62 randomized clinical trials concluded that mesenchymal stem cell therapy was safe compared with placebo.10

No treatment-related serious adverse events reported

The safety summary on the page states that no treatment-related serious adverse events were reported in the meta-analysis.10

How stem cells may interact

How could mesenchymal stem cells help prevent CVD?

Mesenchymal stem cells are among the most studied cell types in regenerative medicine.5-7

Migrate to inflamed or damaged tissue

Pre-clinical and clinical research has shown that mesenchymal stem cells can migrate to inflamed or damaged tissue.6,7

Support formation of new blood vessels

Pre-clinical and clinical research has shown that mesenchymal stem cells can support formation of new blood vessels and improve endothelial function.6-8

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Mesenchymal stem cells can modulate immune responses, reduce harmful inflammation, and protect and repair injured cells.5-7

References

  1. Clarke EA. What is Preventive Medicine? Can Fam Physician. 1974 Nov;20(11):65-8.
  2. World Heart Federation. World Heart Report 2023.
  3. Buja LM, Butany J, eds. Cardiovascular pathology. Academic Press, 2022.
  4. Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018.
  5. Krampera M, Le Blanc K. Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy. Cell Stem Cell. 2021.
  6. Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell. 2011.
  7. Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013.
  8. Hare JM, DiFede DL, Heldman AW et al. POSEIDON-DCM Trial. J Am Coll Cardiol. 2017.
  9. Perin E, Borow K, Henry T, et al. Randomized Trial of Targeted Transendocardial Mesenchymal Precursor Cell Therapy in Patients With Heart Failure. J Am Coll Cardiol. 2023.
  10. Wang Y, Yi H, Song Y. The safety of MSC therapy over the past 15 years: a meta-analysis. Stem Cell Res Ther. 2021.
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