Screening and Follow-Up Tests

All study participants undergo rigorous screening tests. These include biomarkers related to infectious diseases, metabolic health, blood values (including the complete blood count), hormones, inflammation, kidney function, and liver function.

Screening Panel

The Advanced Panel is included in both Baseline and Follow-Up tests.

Baseline

Infectious Diseases

HbsAg (Hepatitis B)
HIV I & II
Syphilis VDRL
Anti HCV (Hepatitis C)

Metabolic

Albumin
ALP
ALT
AST
Potassium
Sodium

Lipid Profile

Total Cholesterol
LDL-Cholesterol
HDL-Cholesterol
Triglycerides
APO A
APO B

Blood Values and Complete Blood Count

HbA1c
Homocysteine
Glucose
Ferritin
CBC

Hormones

Testosterone (male)
TSH (female)

Inflammation

High-sensitive CRP
ESR

Kidney

Creatinine

Liver

Total Bilirubin

Lipid Profile

Total Cholesterol
LDL-Cholesterol
HDL-Cholesterol
Triglycerides
APO A
APO B

Blood Values and Complete Blood Count

HbA1c
Homocysteine
Glucose
Ferritin
CBC

Hormones

Testosterone (male)
TSH (female)

Inflammation

High-sensitive CRP
ESR

Kidney

Creatinine

Liver

Total Bilirubin

Cytokines and Chemokines

Eotaxin
IL-1 RA
IL-1b
IL-2
IL-4
IL-6
IL-7
IL-10
IL-12 p70
IL-13
IL-15
IL-17A
MIP-1A
MIP-1b
IFN-g
MCP-1
GM-CSF
IP-10
TGF-a
TNF-a
TNF-b
VEGF A

Aging

Telomere Length

Total Telomere length (kb)
Average length per telomere end (kb)

DNA Methylation

Total Methylation (5-mC%/total DNA)
5-mC%/cytosine content

Histone 3 Modification

Histone H3K4 methylation (%)

Immunoprofiling

Innate Immune Cells

Total (CD3-CD56+) NK cells %
Mature (CD16+CD56+) NK cells %
Immature (CD16-CD56-) NK cells %
Total monocytes (CD3-CD19-CD14+) %
Classical (CD14hiCD16-) monocytes %
Intermediate (CD14+CD16+) monocytes %
Non-classical (CD16hiCD14+) monocytes %

Adaptive Immune Cells

CD4+ (CD3+CD19-) helper T cells %
Naive (CD45RA+CD27+) CD4+ helper T cells %
Central memory (CD45RA-CD27+) CD4+ helper T cells %
Effector (CD45RA-CD27-) CD4+ helper T cells %
EMRA (CD45RA+CD27-) CD4+ helper T cells %
CXCR3+ CD4+ helper T cells %
Regulatory T cells (CD25+ FOXP3+) %
Activated regulatory T cells (CD25hiFOPX3hi)
CD8+ (CD3+CD19-) cytotoxic T cells %
Naive (CD45RA+CD27+) CD8+ cytotoxic T cells %
Central memory (CD45RA-CD27+) CD8+ T cells %
Effector memory (CD45RA-CD27-) CD8+ cytotoxic T cells %
EMRA (CD45RA+CD27-) CD8+ cytotoxic T cells %
CD19+ B cells %
Naive (IgD+CD27-) B cells %
Immature transitional (CD5+CD38+) B cells %
IgD+ memory (IgD+CD27+) B cells %
Class-switched Memory (IgD-CD27+) B cells %
Total memory (CD27+) B cells %
Plasmablast (CD27+CD38+) %
BAFFR+ B cells %
Regulatory B cells %

Infectious Diseases

HbsAg (Hepatitis B)
HIV I & II
Syphilis VDRL
Anti HCV (Hepatitis C)

Metabolic

Albumin
ALP
ALT
AST
Potassium
Sodium

Lipid Profile

Total Cholesterol
LDL-Cholesterol
HDL-Cholesterol
Triglycerides
APO A
APO B

Blood Values and Complete Blood Count

HbA1c
Homocysteine
Glucose
Ferritin
CBC

Hormones

Testosterone (male)
TSH (female)

Inflammation

High-sensitive CRP
ESR

Kidney

Creatinine

Liver

Total Bilirubin

Lipid Profile

Total Cholesterol
LDL-Cholesterol
HDL-Cholesterol
Triglycerides
APO A
APO B

Blood Values and Complete Blood Count

HbA1c
Homocysteine
Glucose
Ferritin
CBC

Hormones

Testosterone (male)
TSH (female)

Inflammation

High-sensitive CRP
ESR

Kidney

Creatinine

Liver

Total Bilirubin

Cytokines and Chemokines

Eotaxin
IL-1 RA
IL-1b
IL-2
IL-4
IL-6
IL-7
IL-10
IL-12 p70
IL-13
IL-15
IL-17A
MIP-1A
MIP-1b
IFN-g
MCP-1
GM-CSF
IP-10
TGF-a
TNF-a
TNF-b
VEGF A

Aging

Telomere Length

Total Telomere length (kb)
Average length per telomere end (kb)

DNA Methylation

Total Methylation (5-mC%/total DNA)
5-mC%/cytosine content

Histone 3 Modification

Histone H3K4 methylation (%)

Immunoprofiling

Innate Immune Cells

Total (CD3-CD56+) NK cells %
Mature (CD16+CD56+) NK cells %
Immature (CD16-CD56-) NK cells %
Total monocytes (CD3-CD19-CD14+) %
Classical (CD14hiCD16-) monocytes %
Intermediate (CD14+CD16+) monocytes %
Non-classical (CD16hiCD14+) monocytes %

Adaptive Immune Cells

CD4+ (CD3+CD19-) helper T cells %
Naive (CD45RA+CD27+) CD4+ helper T cells %
Central memory (CD45RA-CD27+) CD4+ helper T cells %
Effector (CD45RA-CD27-) CD4+ helper T cells %
EMRA (CD45RA+CD27-) CD4+ helper T cells %
CXCR3+ CD4+ helper T cells %
Regulatory T cells (CD25+ FOXP3+) %
Activated regulatory T cells (CD25hiFOPX3hi)
CD8+ (CD3+CD19-) cytotoxic T cells %
Naive (CD45RA+CD27+) CD8+ cytotoxic T cells %
Central memory (CD45RA-CD27+) CD8+ T cells %
Effector memory (CD45RA-CD27-) CD8+ cytotoxic T cells %
EMRA (CD45RA+CD27-) CD8+ cytotoxic T cells %
CD19+ B cells %
Naive (IgD+CD27-) B cells %
Immature transitional (CD5+CD38+) B cells %
IgD+ memory (IgD+CD27+) B cells %
Class-switched Memory (IgD-CD27+) B cells %
Total memory (CD27+) B cells %
Plasmablast (CD27+CD38+) %
BAFFR+ B cells %
Regulatory B cells %